The team sees a much different look to the side that travelled to Treviso last week in the BKT URC.
Morgan Morris will captain the side for the third successive week with the continued absense of Justin Tipuric.
Gareth Thomas starts at loosehead, Dewi Lake at hooker with Tom Botha completeing the front three.
James Fender partners Adam Beard at lock, whilst Rhys Davies lines up at six. Wales captain Jac Morgan returns on the other flank with Morris starting at eight.
Reuben Morgan-Williams lines up at scrum half, with Owen Williams coming back into the starting lineup after injury starting at 10. Owen Watkin starts with George North at centre.
In the back three, Iestyn Hopkins starts at full back, with Keelan Giles returning from injury on one wing and Luke Morgan on the other.
Ospreys XV to face Benetton:
15. Iestyn Hopkins 14. Luke Morgan 13. George North 12. Owen Watkin 11. Keelan Giles
10. Owen Williams 9. Reuben Morgan-Williams
1. Gareth Thomas 2. Dewi Lake 3. Tom Botha 4. James Fender 5. Adam Beard
6. Rhys Davies 7. Jac Morgan 8. Morgan Morris (captain).
Replacements:
16. Sam Parry 17. Nicky Smith 18. Ben Warren 19. Harri Deaves 20. Tristan Davies
21. Luke Davies 22. Jack Walsh 23. Mat Protheroe
[Lead image: Ospreys Rugby]
