Nicky Smith starts at loosehead, with Dewi Lake lining up at hooker and Tom Botha completing the front three.
Rhys Davies partners with Adam Beard at lock for the second successive week. In the back row, James Ratti is preferred to Harri Deaves, whilst Justin Tipuric is at seven as captain, with Morgan Morris starting at eight.
Reuben Morgan-Williams lines up at scrum half, with Jack Walsh starting at 10. Owen Watkin partners with North at centre, with Kieran Williams missing out completely.
In the back three, inform Max Nagy starts at full back, with Mat Protheroe and Luke Morgan on the wings.
In a strong bench, which contains Wales contingent Gareth Thomas, Morgan and injury returnee Sam Parry, South African speedster Daniel Kasende, on loan from the Cheetahs, could be in line for his first Ospreys appearance.
Ospreys XV to face Dragons:
15. Max Nagy 14. Luke Morgan 13. George North 12. Owen Watkin 11. Mat Protheroe
10. Jack Walsh 9. Reuben Morgan-Williams
1. Nicky Smith 2. Dewi Lake 3. Tom Botha 4. Rhys Davies 5. Adam Beard 6. James Ratti
7. Justin Tipuric (captain) 8. Morgan Morris
Replacements:
16. Sam Parry 17. Gareth Thomas 18. Ben Warren 19. James Fender 20. Jac Morgan
21. Luke Davies 22. Daniel Kasende 23. Luke Scully
[Lead image: Ospreys Rugby]
