The game will take place at the Swansea.com Stadium and is kicking off on Sunday 26th November at 3pm.
Jac Morgan starts for the Ospreys in place of the injured Justin Tipuric, with Morgan Morris captaining the side.
Nicky Smith starts at loosehead, with Dewi Lake lining up at hooker and Tom Botha completing the front three.
James Fender partners with Adam Beard at lock. Rhys Davies lines up at six, with Jac Morgan on the other flank and Morgan Morris starting at eight.
Reuben Morgan-Williams lines up at scrum half, with Jack Walsh at 10. Keiran Williams starts with Owen Watkin in the centres.
In the back three, Max Nagy starts at full back, with Luke Morgan and Cheetahs loanee, Daniel Kasende on the wings.
Scrum half Rewan Kruger, also on loan from the Cheetahs, takes up a place on the bench.
Ospreys Head Coach, Toby Booth, said: “Everyone knows the West Wales Derby is a significant fixture, the boys look at it as soon as the fixture list comes out. We’ve gone well in the fixture in recent times and we know how important it is for our supporters. Often these ones are about how the players keep their heads and keep calm in the pressure cooker.
“We’re mindful of the threats they have and we’re hoping to produce some threats of our own.”
Meanwhile, Scarlets Head coach Dwayne Peel has welcomed back a number of his experienced players for Sunday’s West Wales derby.
The Scarlets starting line-up for the round six BKT United Rugby Championship clash shows eight personnel changes from the team that took the field in Dublin last weekend with skipper Gareth Davies, fly-half Ioan Lloyd and Tongan international Vaea Fifita among those returning.
Johnny McNicholl is also back in the No.15 jersey. Tom Rogers switches to right wing and Steff Evans is recalled on the left.
Joe Roberts partners Johnny Williams in midfield, while Lloyd and Davies are restored as the half-back pairing.
Up front, Wales internationals Wyn Jones and Ryan Elias come into the front row alongside Harri O’Connor. Alex Craig and Jac Price continue at lock, while Fifita gets the nod at blindside flanker in a back row that also contains Teddy Leatherbarrow and Carwyn Tuipulotu.
With Samson Lee on the injury list and Sam Wainwright unavailable for personal reasons, prop Joe Jones, who has signed from Sale Sharks, is named among the replacements.
Dwayne Peel said: “I loved these derbies as a player. The first thing you speak about is the rivalry when you look back at the past games. We haven’t won in Swansea for a while, so that’s a big challenge for us. There’s a lot at stake and we are looking forward to the challenge of going there.
“The Ospreys are a tough team to beat. Their forward pack can be real abrasive. They have always been a combative side and that’s the challenge we have to rise to. We have our own style, they have their style, so it will be good. Derbies tend to throw up different emotions, different styles of play. We are under no illusions, To go there and win, we are going to have to be very good.”
Scarlets
Starting XV: 15 Johnny McNIcholl; 14 Tom Rogers, 13 Joe Roberts, 12 Johnny Williams, 11 Steff Evans; 10 Ioan Lloyd, 9 Gareth Davies (capt); 1 Wyn Jones, 2 Ryan Elias, 3 Harri O’Connor, 4 Alex Craig, 5 Jac Price, 6 Vaea Fifita, 7 Teddy Leatherbarrow, 8 Carwyn Tuipulotu.
Replacements: 16 Shaun Evans, 17 Steff Thomas, 18 Joe Jones, 19 Morgan Jones, 20 Ben Williams, 21 Kieran Hardy, 22 Charlie Titcombe, 23 Ioan Nicholas.
Unavailable players: Kemsley Mathias, Taine Plumtree, Josh Macleod, Dan Davis, Sam Lousi, Ken Owens, Samson Lee, Dan Jones, Sam Costelow, Isaac Young.
Ospreys
Starting XV: 15. Max Nagy; 14. Daniel Kasende; 13. Owen Watkin; 12. Keiran Williams; 11. Luke Morgan; 10. Jack Walsh; 9. Reuben Morgan-Williams; 1. Nicky Smith; 2. Dewi Lake; 3. Tom Botha; 4. James Fender; 5. Adam Beard; 6. Rhys Davies; 7. Jac Morgan; 8. Morgan Morris (Captain)
Replacements: 16. Sam Parry; 17. Gareth Thomas; 18. Rhys Henry; 19. Harri Deaves; 20. Tristan Davies; 21. Rewan Kruger; 22. Dan Edwards; 23. Luke Scully
Unavailable players: Alex Cuthbert, Dom Morris, Ethan Lewis, George North, Huw Sutton, Iestyn Hopkins, Jack Regan, James Ratti, Justin Tipuric, Keelan Giles, Luke Davies, Mat Protheroe, Owen Williams, Toby Fricker, Tom Florence, Will Griffiths.
