Flying high at the top of the standings after the first four rounds, 14/1 shot Clayton is looking for his second night victory in the Welsh capital after beating Price on the way to being victorious in Glasgow on night three.
Price, meanwhile, won night two in Antwerp, where he had the better of the man known as the “Ferret.”
“Two Welsh boys in the final, that would be amazing,” said 51-year-old Clayton.
“Obviously Jonny Clayton picking up the trophy would be a little bit better!
“Hopefully we can do it, fingers crossed we meet in the final.”
“I’m back in and back in Wales playing, so that’s all I want, my favourite tournament, my favourite city.
“There’s no better support than the Welsh. There’s only one major in Wales and it’s the Premier League night, to be a part of that in front of your own crowd is fantastic.”
Clayton admits having fan-backing for both himself and Price – often the target for booing in the past – will be unusual.
“It’s going to be mental, it’s going to be exciting, singing, chanting and they’re all behind us for a change,” he added.
“We’re looking forward to this big time.”
Clayton will first have to overcome World Championship runner-up Gian van Veen in the quarter-finals on Thursday, with the pair splitting their past meetings.
Dutchman Van Veen, on his debut Premier League season, lies second in the early standings after reaching three of the four nightly finals.
The winner will then face either Michael Van Gerwen or Luke Humphries in the Semi-final.
“We’re one win each but he’s at my home in Wales so hopefully that will be to my advantage and Gian can experience the proper Welsh crowds.
“I’m looking forward to this, he’s a great kid, a brilliant player and I’m sure it’ll be a good game.”
Latest Premier League odds courtesy of Betway:
- Luke Littler – 10/11
- Gian van Veen – 5/1
- Luke Humphries – 5/1
- Gerwyn Price – 9/1
- Michael van Gerwen – 10/1
- Jonny Clayton – 14/1
- Stephen Bunting – 25/1
- Josh Rock – 40/1
Night five quarter final match odds:
Gian Van Veen – 8/13 v Jonny Clayton – 13/10
Gerwyn Price – 1/2 v Stephen Bunting – 13/8
