Hooker Sam Parry takes over the captaincy in the absence of Jac Morgan who is rested after playing every minute of Wales’ Six Nations campaign.
Parry is joined in an unchanged front row with Garyn Phillips and Tom Botha from the victory against Glasgow last time out.
British and Irish Lion Adam Beard completes his recovery from a knee injury suffered in Wales’ autumn series defeat by Australia last November to take his place in the second row with James Ratti.
In a positional change Morgan Morse moves to six, Justin Tipuric takes up the other flank and whilst Morris come back in at eight.
Kieran Hardy is preferred to Reuben Morgan-Williams at scrum half where he will continue his half-back partnership with Dan Edwards.
Keiran Williams partners Evardi Boshoff form an unchanged midfield
In the back three, Jack Walsh starts at full back, with Keelan Giles on one wing and Daniel Kasende on the other.
New signing George McGuigan is in line to make his debut from a bench which also sees centre Phil Cokanasiga return from injury.

Ospreys XV to face Glasgow:
Jack Walsh, Daniel Kasende, Evardi Boshoff, Keiran Williams, Keelan Giles, Dan Edwards, Kieran Hardy
Garyn Phillips, Sam Parry (captain), Tom Botha, James Ratti, Adam Beard, Morgan Morse,
Justin Tipuric, Morgan Morris.
Replacements:
George McGuigan, Steffan Thomas, Ben Warren, James Fender, Tristan Davies, Reuben Morgan-Williams, Phil Cokanasiga, Iestyn Hopkins.
[Lead image: Ospreys Rugby]