Nicky Smith’s shoulder injury against Montpellier last weekend keeps out the loosehead with fellow Wales international Gareth Thomas coming into the front three with Dewi Lake and Tom Botha.
James Fender continues his partnership with captain Beard at lock, whilst Rhys Davies comes back into the side for namesake Tristan at six in the only other change to the side, with Harri Deaves on the opposite flank.
Morgan Morris is once again at eight, whilst last weekend’s try scorer Reuban Morgan-Williams lines up at scrum-half.
Kicking duties will be charged to Owen Williams at 10, whilst George North faces off against his former region at centre with Owen Watkin.
In the back three, Jack Walsh starts at full back, with Keelan Giles on one wing and Mat Protheroe on the other.
Ospreys XV to face Scarlets:
15. Jack Walsh 14. Matt Protheroe 13. George North 12. Owen Watkin 11. Keelan Giles
10. Owen Williams 9. Reuben Morgan-Williams
1. Gareth Thomas 2. Dewi Lake 3. Tom Botha 4. James Fender 5. Adam Beard (captain)
6. Rhys Davies 7. Harri Deaves 8. Morgan Morris.
Replacements:
16. Sam Parry 17. Garyn Phillips 18. Ben Warren 19. Morgan Morse 20. Tristan Davies
21. Luke Davies 22. Dan Edwards 23. Luke Morgan.
Head Coach, Toby Booth, said:
“The West Wales Derby is always a hotly contested fixture, it’s the game that means the most to the fans and players of both sides. As a result, we’re expecting a hostile welcome.
“It’s important we go there with the right mindset, as they’ll be looking to bounce back after their defeat to Black Lion last time out.”
[Lead image: Ospreys Rugby]